Effect of thyroidectomy on thyroid eye disease in patients with Grave’s disease

Aims: we aim to compare the effectiveness of thyroidectomy to other forms of treatment in treating Grave's ophthalmopathy patients' ocular manifestations. Methods: In this research conducted at Alexandria University Hospital, Faculty of Medicine, Alexandria University, fifty patients have been selected to undergo thyroidectomy to treat their thyroid-associated eye condition. The study was conducted between January 2020 and December 2020. The surgical procedures performed included total thyroidectomy in 35 patients (70%), 7 patients (14%) underwent Dunhill procedures including complete lobectomy and subtotal resection of the opposite lobe, and subtotal thyroidectomy in 8 patients (16%). Results: Preoperative TRAb levels were frequently markedly high (>2 IU/L). Following surgery, TRAb levels in 33 individuals (1 IU/L - absent) returned to normal, (p 0.001, test t). Significant statistical difference was found between them. The ophthalmopathy index decreased statistically significantly from 6.1±2.32 before treatment to 3.31±2.09 after surgery (p0.001, test t), indicating that the index's value reduced across the board in the group under investigation. The degree of the surgery's impact on postoperative complications is provided. Conclusions: According to this study, surgery helps patients with Graves' illness by lowering their TRAb levels and alleviating their ocular symptoms. To better understand the long-term consequences of thyroidectomy and to develop treatment plans that will increase visual improvement and reduce problems, further investigation and long-term studies are required.